5-Aminoimidazole-4-carboxamide ribonucleotide or AICAR 50MG / AICAR POWDER is an analogue of adenosine monophosphate.  Inside the body, activation of AMPK with AICAR 50MG / AICAR POWDER imitates that the body is exercising and this triggers insulin-independent glucose uptake by muscle cells. This makes AICAR important for improving endurance and burning stored fat. Animal studies have shown that AICAR can potently activate many metabolic genes to increase exercise endurance

AICAR has been used safely in human studies up to concentrations of 25 mg/kg with minimal side effects [8].  

References  of AICAR 

1. Thomson, D.M. and W.W. Winder, AMPK Control of Fat Metabolism in Skeletal Muscle. Acta physiologica (Oxford, England), 2009. 196(1): p. 147-154.
2. Narkar, V.A., et al., AMPK and PPARδ agonists are exercise mimetics. Cell, 2008. 134(3): p. 405-415.
3. Idrovo, J.P., et al., AICAR attenuates organ injury and inflammatory response after intestinal ischemia and reperfusion. Mol Med, 2015. 20: p. 676-83.
4. Winder, W.W., Can Patients with Type 2 Diabetes Be Treated with AMPK-Activators? Diabetologia, 2008. 51(10): p. 1761-1764.
5. Drew, B.G. and B.A. Kingwell, Acadesine, an adenosine-regulating agent with the potential for widespread indications. Expert Opin Pharmacother, 2008. 9(12): p. 2137-44.
6. Miyamoto, L., et al., AICAR stimulation metabolome widely mimics electrical contraction in isolated rat epitrochlearis muscle. American Journal of Physiology-Cell Physiology, 2013. 305(12): p. C1214-C1222.
7. Kirchner, J., B. Brüne, and D. Namgaladze, AICAR inhibits NFκB DNA binding independently of AMPK to attenuate LPS-triggered inflammatory responses in human macrophages. Scientific Reports, 2018. 8(1): p. 7801.
8.  American Journal of Physiology-Endocrinology and Metabolism, 2009. 296(5): p. E1042-E1048.