Company: Zoetissodium hyaluronate injection

10 mg/mL

Product Information

Hylartin V Caution

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Description

HYLARTIN^® V is a sterile pyrogen-free solution of a highly purified, specific fraction of the sodium salt of hyaluronic acid extracted from rooster combs.

CHEMISTRY:

Sodium hyaluronate is a high molecular weight polymer made up of repeating disaccharide units of N-acetylglucosamine and sodium glucuronate linked by beta 1-3 and beta 1-4 glycosidic bonds. HYLARTIN^® V contains only traces of protein.

Pharmacology

Sodium hyaluronate is a natural, physiological substance which occurs extracellularly in connective tissue in both animals and man and is chemically identical in different species. ANIMAL SAFETY:

Acute, sub-acute and chronic toxicity studies in mice, rats, rabbits, dogs, monkeys and horses have not demonstrated any significant adverse reactions or sensitization.  There is always a potential immunological risk with repeated parenteral administration of biological material. CLINICAL STUDIES:

In the other studies, the improvement rate surpassed this figure.

In another case, electrogoniometry was used to objectively show that HYLARTIN^® V can improve the function of arthritic carpal and fetlock joints. HYLARTIN^® V brought return to symmetry with respect to timing and duration of various angular motions of the joints.

Hylartin V Indications

HYLARTIN^® V, is indicated in the treatment of joint dysfunction in horses due to non-infectious synovitis associated with equine osteoarthritis.

Contraindications

None known.

Warning

Do not use in horses intended for human consumption. HYLARTIN^® V must not be administered intravascularly.

Precautions

Used or partially used syringes should be crushed and disposed of in an approved landfill.

Do not use if numerous small air bubbles are present throughout the solution.

Adverse Reactions

The side effects observed in clinical trials were heat (15%), transient edema (12%), and pain (9%) around the treated joint. These side effects have been observed after intra-articular injection. Most of these reactions were of mild nature and in no case did they require the discontinuance of treatment. These reactions subsided in 24 to 48 hours.

For a copy of the Material Safety Data Sheet (MSDS) or to report adverse reactions call Zoetis Inc. at 1-888-963-8471.

Dosage and Administration

2 mL (20 mg) of HYLARTIN^® V given to horses intra-articularly in small and medium size joints (carpal, fetlock). In the treatment of larger joints (hock), the dosage is 4 mL (40 mg). The treatment may be repeated This transient swelling, however, will have no effect on the ultimate clinical result. For best results, the horse should be given two days stall rest before gradually resuming normal activity.

INSTRUCTIONS

OPENING TECHNIQUE

Tear off the paper covering.

Bend the plastic backwards at the central indentation so as to fully expose the white plastic cap.